In collaboration with Prof. Kristen Harris and members of her lab, we interrogated structural features of presynaptic terminals in 3D reconstructions from electron microscopy images from CA1 hippocampal axons that had undergone control stimulation or theta-burst stimulation (TBS) to produce long-term potentiation (LTP). In particular, I quantified structural changes that occur to the cloud of synaptic vesicles after the induction of LTP. A SFN abstract from 2022 can be found here. This project is funded by the National Science Foundation (NSF).

I am working on this project, more to come soon!

3D reconstruction of a presynaptic terminal: vesicles in green, active zone in red, and the distance to the active zone in purple.